You're bound to get vibration with just one U-Joint from everything I've read or experienced.
The rear end pinion and the output shaft of the transmission/clutch have to be parallel with a little difference in height and/or side to side offset for the U-Joints to function smoothly.
As ingersol444 pointed out, "Ujoints like to have a little angle to them. Just match the front and rear angle, and your good to go.". Good advice and well worth listening to.
The U-Joints also have to be aligned on the driveshaft and everything balanced.
Course that's just my opinion.
Mike